Document Detail


The effect of low-dose external beam radiation on extraneural scarring after peripheral nerve surgery in rats.
MedLine Citation:
PMID:  14633305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Scar tissue is an inevitable result of peripheral nerve surgery. A variety of substances have been used to prevent epineurial scarring. In this study, the effect of low-dose radiation therapy on epineurial scarring was investigated. METHODS: Seventy-eight male Sprague-Dawley rats were studied. A total of 60 rats were subjected to one of three types of surgical procedure on the sciatic nerve, as follows: Procedure 1, external neurolysis (n = 20); Procedure 2, abrasive injury (n = 20); and Procedure 3, anastomosis (n = 20). On the left sciatic nerves, 700 cGy external beam radiation was administered 24 hours after surgery, and the right sciatic nerves served as a control group (surgery only). Eighteen animals without surgical intervention were used to establish the fibrotic effect of radiotherapy on normal nerves. A neurological examination was performed weekly. Six weeks after surgery, the extent of extraneural scarring was examined by gross microdissection by means of a numerical grading scheme and histological analysis. Cellular density and surface measurements of scar tissue were also evaluated. RESULTS: The dissection around the nerve was easier in rats treated with low-dose radiation compared with the control group. Furthermore, grading scores in both nerve adherence and nerve separability were significantly lower in treated nerves than in the control group (P < or = 0.05). Low-dose radiotherapy decreased the scores of cellular density and surface measurement of scar tissue (P < or = 0.05). In normal nerves, radiotherapy did not produce any fibrotic effects and the density of fibroblasts/fibrocytes was also very low. CONCLUSION: In the case of surgery or local trauma to peripheral nerve, the use of low-dose radiation therapy may be a safe method of limiting postoperative epineurial scar formation.
Authors:
Aşkin Görgülü; Cem Uzal; Latife Doğanay; Murat Imer; Kenan Eliuz; Sabahattin Cobanoğlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  53     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2004-02-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1389-95; discussion 1395-6     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, School of Medicine, University of Suleyman Demirel, Isparta, Turkey. askingorgulu@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cicatrix / etiology*,  pathology,  prevention & control*
Disease Models, Animal
Fibrosis / etiology,  prevention & control
Male
Neurosurgical Procedures / adverse effects*
Radiotherapy Dosage
Rats
Rats, Sprague-Dawley
Sciatic Nerve / injuries,  radiation effects*,  surgery*
Wound Healing / radiation effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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