Document Detail

The effect of long-term oral captopril treatment on mesenteric blood flow in spontaneously hypertensive rats.
MedLine Citation:
PMID:  8668643     Owner:  NLM     Status:  MEDLINE    
We examined the possibility that changes of the mesenteric resistance play a role in the development of hypertension in spontaneously hypertensive rats (SHRs). Genetically hypertensive (Okamoto) and normotensive Wistar rats (WKYs) were studied after oral treatment for 6 weeks with 100 mg of captopril dissolved in 500 ml water daily. The paired control groups received water. During this treatment, the systolic blood pressure was measured non-invasively with a W+W/BP recorder after preheating of the conscious animals. After these procedures, the rats were anaesthetized, the baseline mesenteric blood flow (MBF, volts) was recorded with a pulsed Doppler flow-meter and the mean arterial blood pressure (MAP) heart rate and mesenteric vascular resistance were also measured. The captopril treatment failed to alter the body weight of SHRs and WKY. In the normotensive group, the MAP was not altered, but the MBF was moderately increased. In contrast, the MAP of the SHRs was markedly decreased, and the MBF was significantly increased. The basal MBF of the SHRs was significantly lower than that of the WKYs. These data suggest that the renin-angiotensin system may exert a tonic vasoconstrictor action on the mesenteric vasculature in SHRs. The increased mesenteric vascular resistance therefore plays an important role in the increased total peripheral resistance in the development of hypertension in SHRs.
Z Rozsa; S Sonkodi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  32     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1996-08-07     Completed Date:  1996-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged Hungary.
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MeSH Terms
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology*
Body Weight
Captopril / administration & dosage,  pharmacology*
Hypertension / drug therapy*,  etiology
Random Allocation
Rats, Inbred SHR
Rats, Inbred WKY
Splanchnic Circulation / drug effects*
Vascular Resistance / drug effects
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 62571-86-2/Captopril

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