Document Detail

The effect of long-term diphenylhydantoin therapy on glucose tolerance and insulin secretion: a controlled trial.
MedLine Citation:
PMID:  6994939     Owner:  NLM     Status:  MEDLINE    
The influence of long-term administration of diphenylhydantoin (DPH) on glucose tolerance and insulin secretion was studied in a random controlled trial in non-epileptic patients receiving the drug for 2 years following recovery from myocardial infarction. While receiving DPH, insulin response to glucose was less than that in the control group, both in absolute terms and when related to the blood glucose level. Despite this, glucose tolerance did not differ from the control group. One month after cessation of DPH, the plasma insulin response had returned to the levels found in the control group, and glucose tolerance had improved to be significantly better than that found in the control group. Thus, the tendency of DPH to impair the insulin response to glucose has been confirmed in this controlled study. However, this does not result in significantly impaired glucose tolerance; it is suggested that the decreased insulin secretion is accompanied by improved insulin sensitivity.
D A Perry-Keene; R G Larkins; P Heyma; C T Peter; D Ross; J G Sloman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical endocrinology     Volume:  12     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-10-21     Completed Date:  1980-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  IM    
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MeSH Terms
Blood Glucose
Clinical Trials as Topic
Glucagon / blood
Glucose Tolerance Test
Insulin / blood,  secretion*
Myocardial Infarction / drug therapy
Phenytoin / blood,  therapeutic use*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 57-41-0/Phenytoin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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