Document Detail

The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits.
MedLine Citation:
PMID:  20690845     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair.
METHODS: Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation.
RESULTS: Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids.
CONCLUSIONS: The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor.
Athanasios Papaspiliopoulos; Kleo Papaparaskeva; Eleni Papadopoulou; John Feroussis; Apostolos Papalois; Aristedes Zoubos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  23     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-7     Citation Subset:  IM    
8th Orthopeadic Department-Shoulder Service, Asklepeion General Hospital, Voula, Athens, Greece.
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MeSH Terms
Anabolic Agents / adverse effects,  pharmacology*
Models, Animal
Nandrolone / adverse effects,  analogs & derivatives*,  pharmacology
Recovery of Function / drug effects*
Restraint, Physical
Rotator Cuff / surgery*
Tendons / drug effects
Wound Healing / drug effects*
Reg. No./Substance:
0/Anabolic Agents; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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