Document Detail

The effect of loading alterations on left ventricular torsion: a simultaneous catheterization and two-dimensional speckle tracking echocardiographic study.
MedLine Citation:
PMID:  20484162     Owner:  NLM     Status:  In-Process    
AIMS: Left ventricular torsion (LVtor) measures the rotational deformation of the myocardium and plays an important role in LV contraction and filling. Two-dimensional (2D) speckle tracking echocardiography (STE) has been validated as a reproducible non-invasive technique to assess LVtor. LVtor is altered in many disease states, but the effects of loading conditions on LVtor have not been established. The aim of this study was to evaluate the effect of load alteration on LVtor as assessed by 2D STE.
METHODS AND RESULTS: Simultaneous echocardiographic imaging and high-fidelity left ventricular pressure measurements were performed in 17 patients with a normal ejection fraction (mean 61 ± 10%) before and after infusion of nitroprusside. All measurements were obtained simultaneously at baseline and then during a steady-state infusion of nitroprusside. Nitroprusside caused a decrease in LV systolic pressure, a decrease in effective arterial elastance (Ea), and a decrease in LV filling pressures. There was a faster rate of LV relaxation with nitroprusside with a decrease in tau from 53 ± 18 to 33 ± 14 ms (P < 0.005). Peak LVtor, apical rotation, twisting rate (TR), and untwisting rate (UTR) each increased after nitroprusside infusion when compared with baseline (P < 0.001). A correlation was found between the change in LV filling pressure and the change of LVtor (r = -0.54, P = 0.02), TR (r = -0.50, P = 0.04), and UTR (r = 0.54, P = 0.02). There was a significant correlation between the change of LVtor and change of Ea (r = -0.66, P < 0.05).
CONCLUSION: LV torsion, TRs, and UTRs are all enhanced in the setting of drug-induced vasodilation, indicating substantial load dependence. These findings must be taken into consideration when evaluating LVtor in disease states.
Sung-Ji Park; Rick A Nishimura; Barry A Borlaug; Paul Sorajja; Jae K Oh
Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  11     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  770-7     Citation Subset:  IM    
Cardiovascular Imaging Center, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determinants of witnessed parental physical violence among university students in transitional Alban...
Next Document:  Field calibration of dosemeters used for routine measurements at flight altitudes.