| The effect of lithium on pupillary response to pulses of light in sheep. | |
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MedLine Citation:
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PMID: 2515554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of lithium carbonate to sheep in the dose range of 600-1800 mg/day resulted in a linearly described rise in lithium levels in plasma and red blood cells. In contrast to the rodent model but in agreement with the human condition, plasma lithium levels exceeded those of red blood cells. Polydipsia and body weight changes were not evident. At plasma levels of 0.70-0.8 mM/l, lithium attenuated the ability of the pupil to constrict in response to 30-sec pulses of light in the 25-150 microW/cm2 intensity range but not the ability to dilate in the dark. Thus, similar to observations in normal human volunteers and bipolar patients, lithium reduces sensitivity to light. The sheep is proposed as a useful model for studying the actions of lithium. |
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Authors:
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J Seggie; M Steiner; N Wright; G Orpen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychiatry research Volume: 30 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-03-08 Completed Date: 1990-03-08 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: IRELAND |
Other Details:
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Languages: eng Pagination: 305-11 Citation Subset: IM |
Affiliation:
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McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Rhythm / drug effects Erythrocytes / metabolism Female Lithium / pharmacokinetics, pharmacology* Lithium Carbonate Photic Stimulation Reflex, Pupillary / drug effects* Sheep |
| Chemical | |
Reg. No./Substance:
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554-13-2/Lithium Carbonate; 7439-93-2/Lithium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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