Document Detail

The effect of lithium carbonate administration on growth in the domestic fowl.
MedLine Citation:
PMID:  3924743     Owner:  NLM     Status:  MEDLINE    
Lithium carbonate is routinely used for the treatment of aggressive behavior disorders in adolescents. The current study was undertaken in order to determine the effect of lithium carbonate administration on growth in a domestic fowl model. The results showed that lithium treatment at a therapeutic level (0.2-2.0 mEq/L) did not significantly alter plasma pH levels, food intake, fecal output or body weight gain. Bivariate and multivariate analysis of tibial dimensions revealed that lithium treatment primarily caused increased growth of proximal epiphyseal height. Allometric analyses indicated that lithium administration increased the growth differential between proximal and distal epiphyses. Two possible mechanisms by which lithium carbonate administration may cause accelerated osseous growth are given.
S Lozanoff; P W Sciulli; J A Negulesco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth     Volume:  49     ISSN:  0017-4793     ISO Abbreviation:  Growth     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-06     Completed Date:  1985-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0205044     Medline TA:  Growth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-104     Citation Subset:  IM    
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MeSH Terms
Body Weight
Bone Development / drug effects
Chickens / growth & development*
Energy Intake
Feces / analysis
Lithium / pharmacology*
Lithium Carbonate
Reg. No./Substance:
554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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