Document Detail


The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis.
MedLine Citation:
PMID:  24911088     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (ESRF) patients treated with continuous ambulatory peritoneal dialysis (CAPD) caused by a one-month lipoate (LA) supplementation at a daily dose of 600mg.
METHODS: The level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of CAPD patients and in the control group.
RESULTS: The sulfane sulfur level in erythrocytes of CAPD patients did not differ compared with healthy volunteers but LA supplementation increased the reactive sulfur concentration. LA elevated also cystathionase activity.
CONCLUSIONS: LA supplementation in ESRF patients treated with CAPD increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties.
Authors:
Ma Gorzata Iciek; Bernadeta Marcykiewicz; Anna Bilska-Wilkosz; Maria Soko Owska-Je Ewicz; Joanna K Apci Ska
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Publication Detail:
Type:  Journal Article     Date:  2014-03-03
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  66     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-06-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  325-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
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