Document Detail

The effect of the lipid A analog E5531 on phospholipid membrane properties.
MedLine Citation:
PMID:  9821951     Owner:  NLM     Status:  MEDLINE    
In order to determine the effect of the lipid A analog, E5531, on phospholipid membranes, we used dipalmitoylphosphatidylcholine (DPPC) and investigated the physicochemical interaction between E5531 and DPPC membranes. E5531 and DPPC are miscible in the bulk phase at 25 degrees C. Within the E5531 mole fraction range (X(E5531)) of 0-0.5, E5531 decreased the zeta potentials of DPPC membranes but did not change the size of the DPPC liposomes. E5531/DPPC mixtures formed liposome-like structures. E5531 increased the fluidity of the DPPC membrane and decreased pyrene diffusion in the membrane. E5531 decreased the phase transition temperature and the cooperative interactions between DPPC molecules. These effects of E5531 on phospholipid membranes were different from those of lipid A from Escherichia coli and Salmonella minnesota.
Y Asai; K Iwamoto; S Watanabe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  438     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-02     Completed Date:  1998-12-02     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd, Gifu, Japan.
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MeSH Terms
1,2-Dipalmitoylphosphatidylcholine / chemistry,  metabolism*
Diffusion / drug effects
Escherichia coli
Lipid A / analogs & derivatives*,  chemistry,  pharmacology
Liposomes / drug effects,  metabolism
Membrane Fluidity / drug effects
Membrane Potentials / drug effects
Membranes, Artificial*
Pyrenes / metabolism
Spectrometry, Fluorescence
Reg. No./Substance:
0/E 5531; 0/Lipid A; 0/Liposomes; 0/Membranes, Artificial; 0/Pyrenes; 129-00-0/pyrene; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine

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