Document Detail


The effect of light on core body temperature is mediated by melatonin in women.
MedLine Citation:
PMID:  8473378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute exposure to bright light at night reduces the nocturnal decline of core body temperature (cBT) and inhibits melatonin secretion in men. Since inhibition of melatonin secretion by beta-adrenergic blockade reduces the nocturnal decline of cBT by 40% in women, experiments were performed to investigate whether the thermoregulatory effect of light is mediated by modifications of melatonin secretion in cycling women. Results show that the elevation of cBT induced by nocturnal exposure to bright light (3000 lux) can be reversed completely by circumventing the decline of serum melatonin levels with concurrent oral administration of melatonin. Our finding establishes melatonin as the mediator of the effect of light on cBT in women and provides a rationale for the use of orally administered melatonin as an aid in the reentrainment of the cBT rhythm in desynchronized conditions.
Authors:
A Cagnacci; R Soldani; S S Yen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  76     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1036-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Reproductive Medicine, University of California-San Diego School of Medicine, La Jolla 92093-0802.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Temperature / radiation effects*
Circadian Rhythm
Female
Humans
Light*
Melatonin / blood,  physiology*
Reference Values
Sex Characteristics*
Grant Support
ID/Acronym/Agency:
HD-12303-14/HD/NICHD NIH HHS; HD-21198-5/HD/NICHD NIH HHS; M01-RR-00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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