Document Detail


The effect of lidocaine on postoperative jejunal motility in normal horses.
MedLine Citation:
PMID:  17461945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure the effect of lidocaine on the duration of the migrating myoelectric complex (MMC) and Phases I, II, and III of the MMC, spiking activity of the jejunum, and number of Phase III events when administered postoperatively to normal horses.
STUDY DESIGN: Nonrandomized cross-over design.
METHODS: Horses were anesthetized and via flank laparotomy 4 silver-silver chloride bipolar electrodes were sutured to the proximal jejunum. Electrical activity was recorded for 6 hours during 3 recording sessions beginning 24, 48, and 72 hours postoperatively. Saline (0.9% NaCl) solution was administered for 3 hours followed by lidocaine administration for 3 hours (1.3 mg/kg bolus intravenously [IV], 0.05 mg/kg/min IV constant rate infusion).
RESULTS: Duration of MMC was unchanged during lidocaine administration (77 minutes-saline versus 105 minutes-lidocaine, P=.16). Durations of Phase I and II were unchanged during lidocaine administration (P=.19 and .056, respectively). Phase III was shorter during lidocaine administration (P=.002). Spiking activity was unchanged at all time periods during lidocaine administration (24 hours-P=.10; 48 hours-P=.95; and 72 hours-P=.12). The number of Phase III events was unchanged over all time periods during lidocaine administration (P=.053).
CONCLUSIONS: Duration of MMC, spiking activity, and number of Phase III events was unchanged during lidocaine administration.
CLINICAL RELEVANCE: Use of lidocaine as a prokinetic agent cannot be supported by this study in normal horses; however, results may differ in clinically affected horses.
Authors:
Melissa Milligan; Warren Beard; Butch Kukanich; Tim Sobering; Sarah Waxman
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  36     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-05-15     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-20     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, Analytical Pharmacology Laboratory, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. mmilliga@vet.ksu.edu
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Local / administration & dosage,  pharmacology*
Animals
Cross-Over Studies
Female
Horses / physiology*,  surgery*
Injections, Intravenous / veterinary
Jejunum / drug effects*,  physiology
Laparoscopy / veterinary
Lidocaine / administration & dosage,  pharmacology*
Male
Myoelectric Complex, Migrating / drug effects*,  physiology
Postoperative Period
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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