Document Detail

The effect of lidocaine on myocardial ischemia with asanguinous reperfusion. An in vitro study.
MedLine Citation:
PMID:  1947908     Owner:  NLM     Status:  MEDLINE    
The effect of lidocaine on the ischemic nor-mothermic rat heart was studied in a Langendorff preparation. Ventricular fibrillation, total retrograde coronary flow and effluent lactate concentration were monitored in preischemia (control), ischemia (20 min) and reperfusion (20 min). Myocardial metabolites were determined in specimens excised at termination of reperfusion. Six hearts were infused with lidocaine in Ringer solution at onset of ischemia (group A) and six with only Ringer solution (group B). Sinus rhythm proceeded directly to diastolic arrest after 17 sec in group A, while all group B hearts showed ventricular fibrillation before arrest at 174 sec. Effluent lactate concentration was reduced in group A during the first 10 min of ischemia, but not subsequently. After 10 min of reperfusion, coronary flow was reduced by 12% in group A and 20% in group B. ATP was higher and ADP, AMP and IMP were lower in group A than in group B after 20 min of reperfusion. Creatine phosphate showed no intergroup difference, but creatine was higher in group B. Cardiac arrest with lidocaine thus reduced lactate formation during ischemia and lessened high-energy phosphate depletion after reperfusion.
L Bengtsson; S Gunnes; B Norman; J Karlsson
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  25     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Adenine Nucleotides / metabolism
Coronary Circulation / drug effects
Heart Arrest, Induced / methods*
Lactates / metabolism
Lactic Acid
Lidocaine / pharmacology*
Myocardial Reperfusion / methods*
Myocardial Reperfusion Injury / prevention & control*
Myocardium / metabolism
Rats, Inbred Strains
Ventricular Fibrillation / prevention & control*
Reg. No./Substance:
0/Adenine Nucleotides; 0/Lactates; 137-58-6/Lidocaine; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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