Document Detail

The effect of leflunomide on cold and vibratory sensation in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  22639744     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: To evaluate the prevalence and risk factors of peripheral neuropathy in patients with rheumatoid arthritis (RA) treated with leflunomide (LEF) by quantitative sensory testing (QST).
METHOD: A total of 94 patients were enrolledin this study, out of which 47 patients received LEF. The other 47 patients received alternative disease-modifying antirheumatic drugs and served as the control group. The demographic characteristics, laboratory findings, concomitant diseases, and medication history were evaluated at the time of QST. The cooling (CDT) and vibratory detection threshold (VDT) as the representative components of QST were measured.
RESULTS: Age, gender, RA duration, ESR, and CRP did not show any significant differences between the two groups. VDT did not demonstrate any significant difference in both groups. However, CDT in LEF group was significantly higher than that of the control group (8.6±2.7 in LEF vs. 5.6±3.8 in control). The proportion of RA patients in the LEF group showing abnormally high CDT was over 2 times greater than that of the control group, but these findings were not statistically significant. Age, RA duration (or LEF medication in LEF group), ESR, and CRP did not show significant correlation with CDT in both groups. VDT significantly correlated with age in both groups.
CONCLUSION: LEF treatment in patients with RA may lead to abnormal CDT in QST. CDT value was not affected by age, RA duration, disease activity, or LEF duration. It remains to be determined whether QST may be a valuable non-invasive instrument to evaluate the early sensory changes in patients with RA taking LEF.
Hyung Kuk Kim; Si-Bog Park; Jong Woo Park; Seong-Ho Jang; Tae-Hwan Kim; Yoon-Kyoung Sung; Jae-Bum Jun
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Publication Detail:
Type:  Journal Article     Date:  2012-04-30
Journal Detail:
Title:  Annals of rehabilitation medicine     Volume:  36     ISSN:  2234-0653     ISO Abbreviation:  Ann Rehabil Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101573065     Medline TA:  Ann Rehabil Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  -    
Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul 133-792, Korea.
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