Document Detail


The effect of lactose maldigestion on the relationship between dairy food intake and colorectal cancer: a systematic review.
MedLine Citation:
PMID:  17044768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dairy food consumption has been inconsistently shown to protect against colorectal cancer (CRC) in case-based studies, and no clear benefits against recurrent colonic polyps (CRP) have been reported. Based on population-based studies we have hypothesized that dairy food intake may have anti-CRC effects at both low intake lactase non-persistent (LNP) populations and at high intake lactase persistent (LP) subjects. We separately analyse existing case-based studies and divide origins into high LNP (>or= 80% LNP prevalence), low LNP (prevalence <or= 20%) and mid LNP countries (21-79% prevalence), which coincide with low, high, and mid quantity dairy food intake regions, respectively. Odds ratios and relative risks (RR) of highest versus lowest dairy intake within each group are analyzed together for assessment of protection against CRC and CRP. Eighty studies met stipulated criteria. Thirteen analyzed the effect on recurrent polyps. Forest plots from 2 regions, high LNP (low dairy food intake) RR = 0.84 [95% confidence interval (CI) = 0.73-0.97) and low LNP (high dairy food intake) RR = 0.80 (95% CI = 0.73-0.88) demonstrated significant protection against CRC. In mixed LNP/LP populations (mid dairy food intake) nonsignificant protection was found RR = 0.92 (95% CI = 0.79-1.06). Similar regional analysis for CRP failed to show significant protective effect in any region. This meta-analysis supports that the highest level of dairy food consumption protects subjects in both high and low LNP regions but not in areas with significant mixed LNP/LP populations. In both groups, dairy foods had no effect on polyp formation, suggesting it may only protect against CRC at late stages of promotion. These results raise the possibility that LNP/LP status may be partly responsible for the discrepant results with respect to the relationship between dairy food consumption and CRC.
Authors:
Andrew Szilagyi; Usha Nathwani; Christina Vinokuroff; José A Correa; Ian Shrier
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Nutrition and cancer     Volume:  55     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-18     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Medicine, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Canada. aszilagy@gas.jgh.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Cohort Studies
Colonic Polyps / epidemiology*,  prevention & control
Colorectal Neoplasms / epidemiology*,  prevention & control
Confidence Intervals
Dairy Products*
Epidemiologic Studies
Humans
Lactase / metabolism*
Lactose Intolerance / physiopathology*
Neoplasm Recurrence, Local
Odds Ratio
Risk Factors
Chemical
Reg. No./Substance:
EC 3.2.1.108/Lactase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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