Document Detail


The effect of ketorolac tromethamine in reducing postoperative inflammation: double-mask parallel comparison with dexamethasone.
MedLine Citation:
PMID:  2619149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anterior chamber fluorophotometry was done after the oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction and posterior chamber intraocular lens insertion before and after surgery. The administration of ketorolac solution 0.5% eye drops before and after surgery decreased the breakdown of the blood-aqueous barrier as much as did dexamethasone sodium phosphate solution 0.1% (dexamethasone solution) eye drops at each postoperative time period as measured by fluorophotometry. Slit-lamp observations of postoperative anterior ocular inflammation were not different between treatment groups. Both ketorolac and dexamethasone solutions were well tolerated by patients. No additional corticosteroids were given to any patients during the study. Therefore, ketorolac solution was as effective as dexamethasone solution in suppressing postoperative inflammation after cataract surgery as measured by fluorophotometry and as observed by slit-lamp examinations. This study confirms prior studies that suggest ketorolac ophthalmic solution 0.5% may be effective and safe as a nonsteroidal antiinflammatory agent for topical use after cataract surgery and intraocular lens implantation and as a substitute for topically applied corticosteroids.
Authors:
A J Flach; N S Jaffe; W A Akers
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of ophthalmology     Volume:  21     ISSN:  0003-4886     ISO Abbreviation:  Ann Ophthalmol     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-03-02     Completed Date:  1990-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210137     Medline TA:  Ann Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  407-11     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of California, San Francisco Medical Center.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Dexamethasone / therapeutic use*
Double-Blind Method
Drug Combinations / therapeutic use
Female
Fluorophotometry
Humans
Ketorolac Tromethamine
Lenses, Intraocular / adverse effects*
Male
Middle Aged
Random Allocation
Tolmetin / analogs & derivatives*,  therapeutic use
Tromethamine / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drug Combinations; 26171-23-3/Tolmetin; 50-02-2/Dexamethasone; 74103-07-4/Ketorolac Tromethamine; 77-86-1/Tromethamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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