Document Detail


The effect of isomeric trans-18:1 acids on the desaturation of palmitic, linoleic and eicosa-8,11,14-trienoic acids by rat liver microsomes.
MedLine Citation:
PMID:  7374357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effects of the positional isomers of trans-18:1 acids on the desaturation of palmitic acid to palmitoleic (delta 9-desaturase), linoleic to gamma-linolenic (delta 6-desaturase) and eicosa-8,11,14-trienoic to arachidonic acid (delta 5-desaturase) were investigated. These trans-18:1 acids were found to be inhibitory for the microsomal delta 6-, delta 9- and delta 5-desaturases of rat liver. The position of the double bond in the trans-18:1 acids seems to be important in determining the degree of inhibition. At inhibitor/substrate ratio of 3:1, the delta 6-desaturase was most strongly inhibited by trans-delta 3, -delta 4, -delta 7 and -delta 15-18:1 isomers, whereas the delta 9-desaturase was most strongly inhibited by trans-delta3, -delta 5, -delta 7, -delta 10, -delta 12, -delta 13 and -delta 16 isomers. At inhibitor/substrate ratio of 6:1, the delta 5-desaturase was most strongly inhibited by delta 3-, delta 9-, delta 13- and delta 15-isomers. When 18:0 was added to the incubations of 16:0, 18:2 and 20:3 at the same I/S ratios used for the trans-18:1 acids, weak inhibition for delta 9- desaturase and no inhibition for delta 5- and delta 6-desaturases was observed.
Authors:
M M Mahfouz; S Johnson; R T Holman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  15     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  100-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / metabolism*
Animals
Fatty Acid Desaturases / antagonists & inhibitors*
Fatty Acids, Essential / deficiency*
Fatty Acids, Unsaturated / metabolism*
Isomerism
Linoleic Acids / metabolism*
Male
Microsomes, Liver / metabolism*
Palmitic Acids / metabolism*
Rats
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Palmitic Acids; 7324-41-6/8,11,14-Eicosatrienoic Acid; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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