Document Detail

The effect of iso-oncotic plasma substitutes: gelatine, dextran 40 (50 g/l) and the effect of Ringer's lactate on the plasma volume in healthy subjects.
MedLine Citation:
PMID:  2483015     Owner:  NLM     Status:  MEDLINE    
82 healthy subjects undergoing Extra-corporeal Shock Wave Lithotripsy (ESWL) under epidural anesthesia were given 1000 ml of either gelatine (Geloplasme), dextran 40, 50 g/l (Isodex) or Ringer's lactate. The purpose of the study was to determine the efficacy of the three described solutions in respect to blood volume changes. A clear differentiation is only possible under absolutely defined physiological conditions and therefore in contrast to other studies, none of these patients was suffering from any shock syndrome or had any blood loss, so no capillary leakage or transcapillary refill problem was present. Plasma volume (PV), colloid oncotic pressure (COP) and hematocrit (Hct) were measured before and 15, 120 and 240 min. after infusion. PV increased both in the gelatine and dextran groups with a higher initial increase in the dextran group. COP increased after 15 min. and Hct decreased after 15 min. in the gelatine and dextran groups. With regard to absolute contraindications this study suggests that dextran 40 can be recommended as plasma substitute due to its higher initial increase in PV, its moderate duration of effect and its low incidence of anaphylactic reaction after a preceding infusion of 20 ml dextran Mw 1000 (Promiten).
W G van den Broek; A Trouwborst; W H Bakker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Belgica     Volume:  40     ISSN:  0001-5164     ISO Abbreviation:  Acta Anaesthesiol Belg     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-29     Completed Date:  1990-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421022     Medline TA:  Acta Anaesthesiol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Department of Anesthesiology, Erasmus University Rotterdam, University Hospital (Dijkzicht), The Netherlands.
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MeSH Terms
Dextrans / pharmacology
Gelatin / pharmacology
Isotonic Solutions / pharmacology
Middle Aged
Osmotic Pressure / drug effects
Plasma Substitutes / pharmacology*
Plasma Volume / drug effects*
Time Factors
Reg. No./Substance:
0/Isotonic Solutions; 0/Plasma Substitutes; 8022-63-7/Ringer's lactate; 9000-70-8/Gelatin; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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