| The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. | |
| | |
MedLine Citation:
|
PMID: 18537995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Determination of drug penetration in diseased skin represents a challenge. OBJECTIVE: To compare dermal microdialysis and tape-strip sampling of drug penetration in normal skin and skin with irritant dermatitis. METHODS: The two methodologies were employed simultaneously in 16 healthy volunteers. Samples were collected in a study of the penetration of a metronidazole cream formulation (Flagyl 1%) applied to forearm skin in both areas with irritant dermatitis and normal skin. Barrier perturbation and the depth of microdialysis probes were quantified by non-invasive bioengineering methods. RESULTS: Microdialysis showed a significant threefold increase in metronidazole penetration in skin with irritant dermatitis compared with unmodified skin. Conversely, the concentration of metronidazole in tape-strip samples was significantly decreased in irritant dermatitis. CONCLUSION: The selection of sampling methodology should be based on the skin layer of interest as well as the integrity of the skin barrier. Whenever the dermal tissue is the target for topical treatment, microdialysis sampling should be the method of choice. |
| | |
Authors:
|
Patricia García Ortiz; Steen Honoré Hansen; Vinod P Shah; Torkil Menné; Eva Benfeldt |
Related Documents
:
|
21977385 - Pilomatrixoma of the adult male breast: a rare tumor with typical ultrasound features. 18089965 - Cancer after renal transplantation. 434845 - Squamous cell carcinoma of the skin and internal malignant neoplasms. 21655375 - Circumareolar mastopexy with multiple glandular plications for symmetry of the contra-l... 3290425 - Childhood tracheobronchial mucoepidermoid carcinoma: a case report and review of the li... 11745285 - Trends in the utilization of androgen-deprivation therapy for patients with prostate ca... |
Publication Detail:
|
Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-01 |
Journal Detail:
|
Title: Contact dermatitis Volume: 59 ISSN: 1600-0536 ISO Abbreviation: Contact Derm. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-07 Completed Date: 2008-09-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: Denmark |
Other Details:
|
Languages: eng Pagination: 23-30 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Gentofte Hospital, 2900 Hellerup, Denmark. patriciagarcia@dadlnet.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Adult Analysis of Variance Area Under Curve Biological Availability Dermatitis, Irritant / metabolism* Dermatologic Agents / administration & dosage, pharmacokinetics* Erythema / chemically induced Female Humans Linear Models Male Metronidazole / administration & dosage, pharmacokinetics* Microdialysis* / methods Middle Aged Skin / injuries, ultrasonography Skin Absorption* Sodium Dodecyl Sulfate Water Loss, Insensible |
| Chemical | |
Reg. No./Substance:
|
0/Dermatologic Agents; 151-21-3/Sodium Dodecyl Sulfate; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The outcome of dimethylglyoxime testing in a sample of cell phones in Denmark.
Next Document: Chinese cupping: a simple method to obtain epithelial grafts for the management of resistant localiz...