Document Detail


The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method.
MedLine Citation:
PMID:  18537995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Determination of drug penetration in diseased skin represents a challenge. OBJECTIVE: To compare dermal microdialysis and tape-strip sampling of drug penetration in normal skin and skin with irritant dermatitis. METHODS: The two methodologies were employed simultaneously in 16 healthy volunteers. Samples were collected in a study of the penetration of a metronidazole cream formulation (Flagyl 1%) applied to forearm skin in both areas with irritant dermatitis and normal skin. Barrier perturbation and the depth of microdialysis probes were quantified by non-invasive bioengineering methods. RESULTS: Microdialysis showed a significant threefold increase in metronidazole penetration in skin with irritant dermatitis compared with unmodified skin. Conversely, the concentration of metronidazole in tape-strip samples was significantly decreased in irritant dermatitis. CONCLUSION: The selection of sampling methodology should be based on the skin layer of interest as well as the integrity of the skin barrier. Whenever the dermal tissue is the target for topical treatment, microdialysis sampling should be the method of choice.
Authors:
Patricia García Ortiz; Steen Honoré Hansen; Vinod P Shah; Torkil Menné; Eva Benfeldt
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-01
Journal Detail:
Title:  Contact dermatitis     Volume:  59     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Gentofte Hospital, 2900 Hellerup, Denmark. patriciagarcia@dadlnet.dk
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Analysis of Variance
Area Under Curve
Biological Availability
Dermatitis, Irritant / metabolism*
Dermatologic Agents / administration & dosage,  pharmacokinetics*
Erythema / chemically induced
Female
Humans
Linear Models
Male
Metronidazole / administration & dosage,  pharmacokinetics*
Microdialysis* / methods
Middle Aged
Skin / injuries,  ultrasonography
Skin Absorption*
Sodium Dodecyl Sulfate
Water Loss, Insensible
Chemical
Reg. No./Substance:
0/Dermatologic Agents; 151-21-3/Sodium Dodecyl Sulfate; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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