Document Detail

The effect of iron supplements and blood transfusion on iron absorption by low birthweight infants fed pasteurized human breast milk.
MedLine Citation:
PMID:  714536     Owner:  NLM     Status:  MEDLINE    
Using serial metabolic balances, iron absorption was measured in six preterm infants (mean gestational age 29 weeks), and two fullterm small for gestational age (SGA) infants, between day 10 and 70 after birth. They were all fed breast milk. Iron supplements (2.5--13 mg/kg day) were given from day 30. Three preterm infants received blood transfusions for anemia. During the first 30 days of life iron balance was negative in the preterm infants (mean +/- SEM = -0.10 +/- 0.02 mg/kg day) and positive in the full term SGA infants (mean +/- SEM = 0.098 +/- 0.02 mg/kg day). In infants who were not tranfused, absorption of supplementary iron was a linear function of iron intake, and corresponded closely to 34% absorption. An iron intake of 5--6 mg/kg day resulted in the absorption of amounts of iron close to those being laid down in utero. Blood transfusion was followed by a reduction in iron absorption; in two cases it became negative, becoming positive again as the hemoglobin fell below about 12.0 g/100 ml. These data show that a mechanism exists in preterm infants for the control of iron absorption which does not operate at the hemoglobin concentrations that prevail in such infants, unless they are transfused.
M J Dauncey; C G Davies; J C Shaw; J Urman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  12     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-01-15     Completed Date:  1979-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  899-904     Citation Subset:  IM    
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MeSH Terms
Anemia, Neonatal / therapy
Blood Transfusion
Fetus / metabolism
Infant, Low Birth Weight*
Infant, Newborn
Infant, Small for Gestational Age
Iron / metabolism*,  therapeutic use
Milk, Human / metabolism*
Reg. No./Substance:

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