Document Detail


The effect of ipriflavone and its main metabolites on theophylline biotransformation.
MedLine Citation:
PMID:  8839679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of ipriflavone and its major metabolites, 7-hydroxy-isoflavone and 7-(1-carboxy-ethoxy)-isoflavone on theophylline metabolism was examined in vitro in human liver microsomes. The compounds inhibited the N-demethylation to 1- or 3-methylxanthine, the major pathway of theophylline metabolism. The effect showed concentration dependence. The oxidation of theophylline to 1,3-dimethyluric acid was slightly affected by ipriflavone and its metabolites and the effect was non-specific. Results indicate that the reduction of theophylline clearance by concomitant ipriflavone administration observed by Takahashi et al. [Takahashi J., Kawakatsu K., Wakayama T., Sawaoka H. (1992): Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur. J. Clin. Pharmacol., 43, 207-208] is primarily due to an interaction of the inhibitory ipriflavone and/or its metabolites with cytochrome P450 enzyme(s) that mediate N-demethylation of theophylline.
Authors:
K Monostory; L Vereczkey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of drug metabolism and pharmacokinetics     Volume:  21     ISSN:  0378-7966     ISO Abbreviation:  Eur J Drug Metab Pharmacokinet     Publication Date:    1996 Jan-Mar
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  7608491     Medline TA:  Eur J Drug Metab Pharmacokinet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Affiliation:
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / metabolism,  pharmacology*
Biotransformation
Bone Remodeling
Bronchodilator Agents / blood,  metabolism,  pharmacokinetics*
Humans
Isoflavones / metabolism,  pharmacology*
Male
Microsomes, Liver / metabolism*
Theophylline / blood,  metabolism,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Bronchodilator Agents; 0/Isoflavones; 35212-22-7/ipriflavone; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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