Document Detail

The effect of ion composition on cellular membrane potentials during selective coronary arteriography.
MedLine Citation:
PMID:  6090335     Owner:  NLM     Status:  MEDLINE    
An animal experimental study on seven thoracotomized dogs was designed to investigate the effects of intracoronarily injected sodium meglumine diatrizoate on myocardial electrophysiology and to evaluate the contribution of the corresponding changes of electrolyte levels in coronary blood. For this purpose the effects of alterations in the Na+-, K+- and Ca++-concentrations in coronary blood were studied separately by intracoronarily injected model solutions. Membrane potentials were recorded from the left ventricular myocardium by a modified microelectrode technique which is applicable to the beating and blood perfused heart in situ. Following selective coronary arteriography there was a temporary hyperpolarization of resting potentials and a prolongation of action potentials which may be explained by a contrast-induced local deficiency of potassium and calcium ions and by a relative prevalence of sodium ions in coronary blood. In selective coronary arteriography the synchronicity of cardiac excitation is disturbed by the regional prolongation of action potentials, which may induce ventricular arrhythmias.
H G Wolpers; D Baller; A Hoeft; H Korb; R Schräder; J Zipfel; G Hellige
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  19     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-11-16     Completed Date:  1984-11-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Angiography / methods
Calcium / blood
Coronary Angiography*
Diatrizoate / analogs & derivatives*
Diatrizoate Meglumine / pharmacology*
Heart / drug effects*,  physiology
Ion Channels / drug effects*
Membrane Potentials / drug effects
Myocardium / metabolism
Potassium / blood
Sodium / blood
Reg. No./Substance:
0/Ion Channels; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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