Document Detail


The effect of intravitreal bevacizumab and ranibizumab on cutaneous tensile strength during wound healing.
MedLine Citation:
PMID:  23378736     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the effect of intravitreal bevacizumab and ranibizumab on wound tension and by histopathology during cutaneous wound healing in a rabbit model and to compare this effect to placebo intravitreal saline controls 1 and 2 weeks following intravitreal injection.
METHODS: A total of 120 New Zealand white rabbits were randomly assigned to one of three treatment groups each consisting of 40 rabbits. Each group received intravitreal injections of bevacizumab, ranibizumab, or normal saline. Immediately afterwards, each rabbit underwent four 6 mm full-thickness dermatologic punch biopsies. Twenty rabbits from each agent group underwent wound harvesting on day 7 or day 14. The skin samples were stained for CD34 for vascular endothelial cells on day 7, and maximal wound tensile load was measured on days 7 and 14. Quantitative assessment of mean neovascularization (MNV) scores was obtained from 10 contiguous biopsy margin 400× fields of CD34-stained sections by two independent observers.
RESULTS: Wound tension reading means (N) with standard error and adjusted P-values on day 7 were: saline placebos, 7.46 ± 0.87; bevacizumab, 4.50 ± 0.88 (P = 0.041); and ranibizumab, 4.67 ± 0.84 (P = 0.025). On day 14 these were: saline placebos, 7.34 ± 0.55; bevacizumab, 6.05 ± 0.54 (P = 0.18); and ranibizumab 7.99 ± 0.54 (P = 0.40). MNV scores in CD34 stained sections were: saline controls, 18.31 ± 0.43; bevacizumab, 11.02 ± 0.45 (P < 0.0001); and ranibizumab, 13.55 ± 0.43 (P < 0.0001). The interobserver correlation coefficient was 0.928.
CONCLUSION: At day 7, both anti-vascular endothelial growth factor (anti-VEGF) agents had significantly suppressed MNV scores and exerted a significant reduction of cutaneous wound tensile strength compared with saline controls. At day 14, neither agent produced a significant effect on tensile wound strength. Since angiogenesis is an integral component of the proliferative phase of wound healing, we encourage clinicians to be aware of their patients' recent surgical history during intravitreal anti-VEGF therapy and to consider refraining from their use during the perioperative period.
Authors:
John B Christoforidis; Jillian Wang; Angela Jiang; James Willard; Cedric Pratt; Mahmoud Abdel-Rasoul; Sashwati Roy; Heather Powell
Related Documents :
23725216 - The effect of a systemic angiotensin receptor blocker on vascular endothelial growth fa...
8554156 - Greater risk of incisional hernia with morbidly obese than steroid-dependent patients a...
23965916 - Correction of lower extremity angular deformities in skeletal dysplasia with hemiepiphy...
7977996 - Cystic duct leaks in laparoscopic cholecystectomy.
11096216 - Combined therapy of corticosteroid and azathioprine in hypertrophic cranial pachymening...
3924466 - Second line therapy in rheumatoid arthritis--a four year prospective study.
Publication Detail:
Type:  Journal Article     Date:  2013-01-24
Journal Detail:
Title:  Clinical ophthalmology (Auckland, N.Z.)     Volume:  7     ISSN:  1177-5467     ISO Abbreviation:  Clin Ophthalmol     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-02-05     Revised Date:  2013-07-10    
Medline Journal Info:
Nlm Unique ID:  101321512     Medline TA:  Clin Ophthalmol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  -    
Affiliation:
Department of Ophthalmology and Vision Science, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
UL1 TR000090/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: rol...
Next Document:  Intravitreal bevacizumab combined with plaque brachytherapy reduces melanoma tumor volume and enhanc...