| The effect of intravenous verapamil on cerebral hemodynamics in a migraine patient with hemiplegia. | |
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MedLine Citation:
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PMID: 10669185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the use of intravenous verapamil in a migraine patient with hemiplegia to reverse the symptomatology and hemodynamics of the middle cerebral artery as determined by transcranial Doppler. CASE SUMMARY: A 31-year-old white woman was admitted with an acute exacerbation of migraine with hemiplegia. A transcranial Doppler showed an increased flow velocity through the middle cerebral artery consistent with a migrainous process. The patient was treated with verapamil 5 mg iv and the hemiplegia gradually resolved. A transcranial Doppler indicated that the flow velocity through the middle cerebral artery was decreased after verapamil administration, indicating reversal of the vasospasm. DISCUSSION: Transcranial Doppler has not been previously used to determine the effect of intravenous verapamil on the migrainous process. Intravenous verapamil reversed the altered hemodynamics of the middle cerebral artery as determined by transcranial Doppler. This finding correlated with the gradual resolution of hemiplegia. Whether both subjective and objective findings in this patient can be attributed to the reversal of the cerebral artery hemodynamics is not known. CONCLUSIONS: Intravenous verapamil appears to reverse the vasospasm that may be associated with a migrainous process. Whether this effect is solely responsible for clinical improvement is not known. Verapamil may be a consideration for the treatment of intractable migraine, especially when there is evidence of spasm of the major cerebral arteries. |
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Authors:
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T M Ng; A Kohli; S C Fagan; A E Mohamed; G Geiszt |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 34 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-24 Completed Date: 2000-02-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, Wayne State University, Detroit, MI, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium Channel Blockers / administration & dosage, therapeutic use* Cerebrovascular Circulation / drug effects* Female Hemiplegia / complications, drug therapy* Hemodynamics / drug effects Humans Injections, Intravenous Middle Cerebral Artery / drug effects, physiology Migraine Disorders / complications, drug therapy* Time Factors Ultrasonography, Doppler, Transcranial Verapamil / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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