Document Detail

The effect of intravenous tenoxicam on pruritus in patients receiving epidural fentanyl.
MedLine Citation:
PMID:  10209375     Owner:  NLM     Status:  MEDLINE    
In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery during which epidural fentanyl was administered. All patients had an epidural catheter inserted at the time of surgery. Epidural fentanyl 100 micrograms was administered intra-operatively and infused at a concentration of 2 for 48 h postoperatively. All patients received a standard anaesthetic and, in addition, the study group had a 20 mg bolus of tenoxicam intravenously, intra-operatively. Patients receiving tenoxicam demonstrated significantly lower pruritus and pain scores at 30 min, 2, 4, 8 and 24 h postoperatively as well as reduced pethidine requirements for breakthrough pain in the first 24 h. In conclusion, tenoxicam 20 mg significantly reduces the incidence and severity of postoperative pruritus in patients who received peri-operative epidural fentanyl. In addition, it significantly reduces pain and further analgesic requirements postoperatively.
S Colbert; D M O'Hanlon; F Chambers; D C Moriarty
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  54     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  AIM; IM    
Department of Anaesthesia, Mater Misericordiae Hospital, Dublin 7, Ireland.
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MeSH Terms
Abdomen / surgery
Analgesia, Epidural / adverse effects
Analgesics, Opioid / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Cyclooxygenase Inhibitors / therapeutic use*
Fentanyl / adverse effects
Injections, Intravenous
Middle Aged
Pain, Postoperative / prevention & control
Piroxicam / analogs & derivatives*,  therapeutic use
Prospective Studies
Pruritus / chemically induced,  prevention & control*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 36322-90-4/Piroxicam; 437-38-7/Fentanyl; 59804-37-4/tenoxicam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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