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The effect of intravenous perfluorocarbon emulsions on whole-body oxygenation after severe decompression sickness.
MedLine Citation:
PMID:  22437970     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Decompression sickness (DCS) results from a decrease in ambient pressure leading to supersaturation of tissues with inert gas and bubble formation. Perfluorocarbons (PFCs) are able to dissolve vast amounts of non-polar gases. Intravenous (IV) PFC emulsions reduce both morbidity and mortality associated with DCS, but the mechanism of this protective effect has not yet been demonstrated.
METHODS: Juvenile Dorper-cross sheep (n = 31) were anaesthetised and instrumented for physiological monitoring, IV fluid administration and blood sampling. Animals were compressed in air in a hyperbaric chamber to 608 kPa for 30 minutes and then rapidly decompressed. Upon decompression, animals were randomly assigned to receive 6 mmol per L of PFC or saline over 10 minutes beginning immediately after chamber exit. Arterial and mixed venous bloods were drawn at 5, 10, 15, 30, 60 and 90 minutes to examine pH, partial pressures of oxygen and carbon dioxide, oxygen saturation and electrolytes.
RESULTS: Compared to saline, PFC administration increased arterial oxygen content (16.33 ± 0.28 vs. 14.68 ± 0.26 ml per dL, P < 0.0001), mixed venous oxygen content (12.56 ± 0.28 vs. 11.62 ± 0.26 ml per dL, P = 0.0167), oxygen delivery (14.83 ± 0.28 vs. 13.39 ± 0.26 mmol per L kg, P = 0.0003) and tissue oxygen consumption (3.30 ± 0.15 vs. 2.78 ± 0.13 mmol per L kg, P = 0.0149) but did not increase extraction ratio (0.22 ± 0.012 vs. 0.21 ± 0.011, P = 0.5343).
CONCLUSIONS: It is likely that the improved oxygenation explains, at least in part, the previously-observed therapeutic effects of PFCs in DCS.
Cameron R Smith; J Travis Parsons; Jiepei Zhu; Bruce D Spiess
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diving and hyperbaric medicine : the journal of the South Pacific Underwater Medicine Society     Volume:  42     ISSN:  1833-3516     ISO Abbreviation:  Diving Hyperb Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282742     Medline TA:  Diving Hyperb Med     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  10-7     Citation Subset:  IM    
Departments of Anesthesiology, Physiology, Virginia Commonwealth University Reanimation Engineering Shock Center (VCURES), PO Box 980695, Richmond, Virginia 23298-0695, USA, Phone: +01-(0)804-827-2205, Fax: +01-(0)804-828-6413, E-mail:
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