Document Detail


The effect of intravenous metoclopramide on blood pressure in normotensive and hypertensive subjects.
MedLine Citation:
PMID:  8880288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study we evaluated the effect of intravenous metoclopramide on blood pressure in normotensive (untrained, football players, runners) and hypertensive subjects. There was a decrease in blood pressure only observed in untrained female subjects and this was greater in hypertensive subjects. In football players and runners the decrease in blood pressure was not statistically significant. There was no significant effect on heart rate. The probable mechanism of this new pharmacological effect of metoclopramide is unknown, however, research is now in progress to define its mechanism of action.
Authors:
M Blanco; I Jelambi; G Pérez; J Gómez; T Franco; N Hurtado; M Velasco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  34     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  390-2     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas, SA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Dopamine Antagonists / pharmacology*
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy
Infusions, Intravenous
Male
Metoclopramide / pharmacology*
Middle Aged
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 364-62-5/Metoclopramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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