Document Detail

The effect of intrauterine vascular compromise on further development of corpus spongiosum and urethra.
MedLine Citation:
PMID:  8199128     Owner:  NLM     Status:  MEDLINE    
An in-utero experimental study was performed to evaluate the effects of intrauterine vascular compromise on further development of corpus spongiosum and male urethra. Thirty time-mated pregnant New Zealand white rabbits on their twenty-third day of gestation were used. Deterioration of the blood supply of the corpus spongiosum and urethra was attempted by electrocauterizing the perineum adjacent to the root of the phallus without damaging the corpus spongiosum and urethra, under the operating microscope. A bipolar cautery was carried out using a specially designed forceps having 100 microns interspaced fixed tips. Five experimental and seven control live male litters were delivered at term by Cesarean sections. Their anogenital regions were examined histopathologically. While the corpus spongiosum extended as long as the corpus cavernosum to the tip of phallus in control litters, the corpus spongiosum ended under the skin in one of the experimental group and in the other four was shorter than the corpus cavernosum. In the latter group, no histopathological evidence of tissue destruction which might be related to electrocauterization, was found. Similar to the pathogenesis encountered in intestinal atresia, a vascular insult which might occur even after the completion of organogenesis, may affect the fate of the corpus spongiosum and urethra. Localized ischemia resulting from local vascular insults may explain, at least in theory, the pathogenesis of some congenital anomalies of corpus spongiosum and urethra such as hypospadias.
F Kizilcan; F C Tanyel; N Cakar; N Büyükpamukçu; A Hiçsönmez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  4     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-05     Completed Date:  1994-07-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
Department of Pediatric Surgery, Hacettepe University Medical Center, Ankara, Turkey.
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MeSH Terms
Electrocoagulation / adverse effects*
Hypospadias / etiology*
Penis / abnormalities*,  blood supply,  embryology
Prenatal Exposure Delayed Effects*
Urethra / abnormalities*,  blood supply,  embryology

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