| The effect of intraperitoneally administered microcystin-LR on the gastrointestinal tract of Balb/c mice. | |
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MedLine Citation:
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PMID: 15033322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microcystin-LR (MCLR) has been associated with the development of gastrointestinal complaints in people ingesting cyanobacterial bloom contaminated water. The symptoms usually present a day or two after exposure raising questions as to the toxic effects of MCLR on the gastrointestinal tract. This study investigated the apoptotic effect of ip administered MCLR over time on the duodenum, jejenum and ileum of mice receiving a single 75% LD(50) dose. The apoptotic index was significantly raised in all sections at 8 h post exposure (pe) and continued to rise for the 16, 24 and 32 h pe groups, while the glycogen levels were normal at 24 h pe. The duodenum exhibited the most significant increase in apoptotic index overall, followed by the jejenum and ileum. Immunohistochemistry indicated the presence of MCLR in the lamina propria suggesting a role for MCLR in the induction of apoptosis in the GIT of mice exposed to a single sublethal dose of MCLR. |
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Authors:
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Nicolette Botha; Maryna van de Venter; Tim G Downing; Enid G Shephard; Michelle M Gehringer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 43 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-22 Completed Date: 2004-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 251-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Microbiology, University of Port Elizabeth, P.O. Box 1600, Port Elizabeth 6000, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Bacterial Toxins / administration & dosage, pharmacology* Cyanobacteria Duodenum / drug effects Female Ileum / drug effects Immunohistochemistry Injections, Intraperitoneal Intestine, Small / drug effects* Jejunum / drug effects Mice Mice, Inbred BALB C Microcystins Peptides, Cyclic / administration & dosage, pharmacology* Specific Pathogen-Free Organisms Water Microbiology |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Microcystins; 0/Peptides, Cyclic; 101043-37-2/cyanoginosin LR |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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