Document Detail

The effect of intrapartum epidural analgesia on nulliparous labor: a randomized, controlled, prospective trial.
MedLine Citation:
PMID:  8238138     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine the effect of epidural analgesia on nulliparous labor and delivery. STUDY DESIGN: Normal term nulliparous women in early spontaneous labor were randomized to receive either narcotic or epidural analgesia. RESULTS: When compared with the group receiving narcotic analgesia (n = 45), the group receiving epidural analgesia (n = 48) had a significant prolongation in the first and second stages of labor, an increased requirement for oxytocin augmentation, and a significant slowing in the rate of cervical dilatation. Epidural analgesia was associated with a significant increase in malposition (4.4% vs 18.8%, p < 0.05). Cesarean delivery occurred more frequently in the epidural group (2.2% vs 25%, p < 0.05), primarily related to an increase in cesarean section for dystocia (2.2% vs 16.7%, p < 0.05). CONCLUSIONS: In a randomized, controlled, prospective trial epidural analgesia resulted in a significant prolongation in the first and second stages of labor and a significant increase in the frequency of cesarean delivery, primarily related to dystocia.
J A Thorp; D H Hu; R M Albin; J McNitt; B A Meyer; G R Cohen; J D Yeast
Related Documents :
2523708 - Phospholipases in the control of human parturition.
15715528 - Normal labor associated with changes in uterine heparan sulfate proteoglycan expression...
45068 - Spontaneous labor and elective induction--a prospective randomized study. i. effects on...
7414458 - Third trimester induction of labor with fetal death in utero.
19790148 - Acute liver failure at 26 weeks' gestation in a patient with sickle cell disease.
7489068 - Correlates of multigravida women's binge drinking during pregnancy. a longitudinal study.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-26     Completed Date:  1993-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  851-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, St. Luke's Hospital, Kansas City, MO.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesia, Epidural / adverse effects*
Analgesia, Obstetrical / adverse effects*
Analysis of Variance
Apgar Score
Bupivacaine / adverse effects,  therapeutic use
Cesarean Section / statistics & numerical data
Delivery, Obstetric
Fetal Blood / chemistry,  drug effects
Injections, Intravenous
Labor Presentation
Labor, Obstetric / drug effects*
Meperidine / administration & dosage,  therapeutic use
Oxytocin / therapeutic use
Pain Measurement
Promethazine / administration & dosage,  therapeutic use
Prospective Studies
Time Factors
Reg. No./Substance:
2180-92-9/Bupivacaine; 50-56-6/Oxytocin; 57-42-1/Meperidine; 60-87-7/Promethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Elevated second-trimester human chorionic gonadotropin and subsequent pregnancy-induced hypertension...
Next Document:  The association between prenatal stress and infant birth weight and gestational age at birth: a pros...