Document Detail

The effect of intrahippocampal injection of kainic acid on corticosterone release in rats.
MedLine Citation:
PMID:  2164646     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate whether the hippocampus exerts a modulatory effect on the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Kainic acid was stereotaxically injected into the CA1 pyramidal cell layer of the dorsal hippocampus, causing histological and behavioural changes typical of kainic acid toxicity. The CA3 pyramidal cells of the dorsal hippocampus were selectively lesioned. Rats treated with kainic acid were hyperactive, executed clockwise rotatory movements and displayed epileptic seizures. The acute excitatory effect of kainic acid on glutamatergic receptors in the hippocampus resulted in an elevation in plasma corticosterone levels, suggesting a stimulation of HPA axis activity. Direct or indirect stimulation of the CA1 pyramidal cells of the dorsal hippocampus appeared to have caused the increase in corticosterone secretion.
W M Daniels; A Jaffer; A H Engelbrecht; V A Russell; J J Taljaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  15     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, Republic of South Africa.
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MeSH Terms
Adrenal Glands / physiology
Behavior, Animal / drug effects
Circadian Rhythm
Corticosterone / secretion*
Hippocampus / drug effects,  physiology*
Hypothalamus / physiology
Kainic Acid / administration & dosage,  pharmacology*
Motor Activity / drug effects
Pituitary Gland / physiology
Rats, Inbred Strains
Receptors, Glutamate
Receptors, Neurotransmitter / drug effects,  physiology
Reg. No./Substance:
0/Receptors, Glutamate; 0/Receptors, Neurotransmitter; 487-79-6/Kainic Acid; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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