| The effect of intracerebroventricular 3-mercaptopropionic acid on blood pressure and heart rate in the rat. | |
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MedLine Citation:
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PMID: 4005607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracerebroventricular (i.c.v.) injection of 3-mercaptopropionic acid (3-MP, 250 micrograms/10 microliter) elicited an elevation of blood pressure in a dose-dependent manner in anaesthetized rats. This elevation of blood pressure could be blocked by treatment with amino-oxyacetic acid (AOAA, 25 mg/kg, i.p.) 5 h prior to the i.c.v. injection of 3-MP. Given intraperitoneally (i.p.), 3-MP (75 mg/kg) had no effect on blood pressure or heart rate. I.c.v. injection of 3-MP produced a selective decrease in GABA content in the diencephalon and mesencephalon, whereas i.p. injection of 3-MP caused a decrease in GABA content in all regions of brain, including telencephalon, diencephalon, mesencephalon, pons and medulla. The results suggest that the elevation of blood pressure induced by i.c.v. injection of 3-MP may be the result of a selective depletion of GABA in diencephalon and/or mesencephalon. Decreases in GABA content in brain regions other than diencephalon and mesencephalon may lead to an opposite effect in modulating blood pressure. |
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Authors:
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S G Fan; J P Zhou; H Xu; J S Han |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 337 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-08-21 Completed Date: 1985-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 184-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Mercaptopropionic Acid
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administration & dosage*,
pharmacology 4-Aminobutyrate Transaminase / antagonists & inhibitors Aminooxyacetic Acid / pharmacology Animals Blood Pressure / drug effects* Brain Chemistry / drug effects Female Heart Rate / drug effects* Injections, Intraventricular Rats Sulfhydryl Compounds gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Sulfhydryl Compounds; 107-96-0/3-Mercaptopropionic Acid; 56-12-2/gamma-Aminobutyric Acid; 645-88-5/Aminooxyacetic Acid; EC 2.6.1.19/4-Aminobutyrate Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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