Document Detail

The effect of intracameral adrenaline infusion on pupil size, pulse rate, and blood pressure during phacoemulsification.
MedLine Citation:
PMID:  9715439     Owner:  NLM     Status:  MEDLINE    
Pupillary constriction during phacoemulsification (phaco) and irrigation/aspiration (I/A) is found to be the major cause of iris damage, incomplete cortex removal, posterior capsule rupture, vitreous loss and even posterior lens material dislocation. Cataract surgery is performed more easily if mydriasis can be maintained. Irrigation fluid containing adrenaline is thought to be of benefit in this respect. We designed a prospective study assessing the efficacy and safety of using perioperative adrenaline during phacoemulsification, as an adjunct to preoperative topical mydriatics. Forty-two cases were randomized to receive intraocular irrigation fluid with or without 1:1,000,000 adrenaline, as a study or control group. Diameter of the pupil, pulse rate, systolic and diastolic pressure before-phaco, after-phaco-before-I/A and after-I/A were measured. All of the operations were performed by the same surgeon with the same technique. The pupil size after-phaco-before-I/A was 8.00 mm in the study group and 5.96 mm in the control group. The mydriasis maintained during phacoemulsification was significantly greater in the study group, p < 0.00001. The pupil size after-I/A was 8.03 mm in the study group, and 5.54 mm in the control group. The mydriasis maintained during I/A was significantly greater in the study group, p < 0.00001. Pulse rate and blood pressure in patients of the study group, even those with hypertension, showed no significant fluctuation during the surgery. We concluded that intraocular irrigation with 1:1,000,000 adrenaline was a safe and effective way of maintaining mydriasis during cataract surgery.
S W Liou; C Y Yang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  14     ISSN:  1080-7683     ISO Abbreviation:  J Ocul Pharmacol Ther     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-14     Completed Date:  1998-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  IM    
Department of Ophthalmology, Taipei Municipal Jen-Ai Hospital, Taiwan, Republic of China.
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MeSH Terms
Blood Pressure / drug effects*
Epinephrine / administration & dosage*
Heart Rate / drug effects*
Irrigation / methods
Mydriatics / administration & dosage*
Prospective Studies
Pupil / drug effects*
Reg. No./Substance:
0/Mydriatics; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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