| The effect of intraaortic balloon counterpulsation on regional myocardial blood flow and oxygen consumption in the presence of coronary artery stenosis in patients with unstable angina. | |
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MedLine Citation:
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PMID: 7094269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether a reduction in myocardial oxygen demand or an increase in coronary blood flow or both are responsible for the salutory effect of intraaortic balloon counterpulsation (IABP) in relieving medically refractory angina, we assessed these variables in six patients in whom IABP was required for relief of myocardial ischemia. IABP decreased the rate-pressure product and aortic end-diastolic pressure, and the peak systolic aortic pressure and regional myocardial oxygen consumption declined in all but one patient. Peak and mean aortic diastolic pressures increased. Changes in regional coronary blood flow paralleled changes in peak systolic aortic pressure (r = 0.92, p less than 0.007). Thus, relief of angina during IABP could not be ascribed to an increase in regional coronary blood flow. Reduction of myocardial oxygen consumption is the most likely mechanism by which IABP relieves myocardial ischemia in patients with unstable angina pectoris. |
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Authors:
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D O Williams; K S Korr; H Gewirtz; A S Most |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 66 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-09-17 Completed Date: 1982-09-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 593-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / surgery* Assisted Circulation* Constriction, Pathologic Coronary Circulation* Coronary Disease / complications, physiopathology* Female Hemodynamics Humans Intra-Aortic Balloon Pumping* Male Middle Aged Myocardium / metabolism Oxygen Consumption* |
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