Document Detail


The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
MedLine Citation:
PMID:  17888432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effect of interleukin-6 (IL-6) on ciliary activity within the human fallopian tube in vitro. DESIGN: An experimental laboratory-based study. SETTING: University teaching hospital. PATIENT(S): Fallopian tube specimens were obtained from eight women undergoing hysterectomy for fibroid uterus. MAIN OUTCOME MEASURE(S): Ciliary beat frequency (CBF) in the human fallopian tube. INTERVENTION(S): After baseline CBF measurements, increasing concentrations of IL-6 (10 pg/mL, 100 pg/mL, and 1000 pg/mL) were applied to fallopian tube mucosa explants and CBF measurements repeated. An anti-IL-6 monoclonal antibody was added and CBF measured once more. Negative and antibody-only control samples were used. RESULT(S): The CBF remained unchanged with the addition of IL-6 at concentrations of 10 pg/mL and 100 pg/mL but IL-6 at 1000 pg/mL significantly decreased CBF, an effect abolished by the addition of the specific antibody. CONCLUSION(S): These data suggest that IL-6 has an inhibitory effect on ciliary activity, suggesting a possible role for this cytokine in the subfertility process. This finding may be important in conditions where there are increased IL-6 levels in the peritoneal fluid, such as endometriosis and pelvic inflammatory disease.
Authors:
A Papathanasiou; O Djahanbakhch; E Saridogan; R A Lyons
Publication Detail:
Type:  In Vitro; Journal Article     Date:  2007-09-20
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-4     Citation Subset:  IM    
Affiliation:
Academic Department of Obstetrics and Gynaecology, Bart's and The London and Newham University Hospitals and Queen Mary's School of Medicine and Dentistry, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / pharmacology
Cilia / drug effects*,  physiology*
Fallopian Tubes / cytology
Female
Humans
Interleukin-6 / administration & dosage,  immunology,  pharmacology*
Leiomyoma / surgery
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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