Document Detail

The effect of interferon-gamma on rejection and neutrophil function following transplantation.
MedLine Citation:
PMID:  8301156     Owner:  NLM     Status:  MEDLINE    
Rats were used as a model for a living heterotopic cardiac allograft organ transplant. Rats treated in this model with recombinant rat interferon-gamma (IFN-gamma) showed accelerated rejection in a dose-dependent fashion. However, rats treated with maintenance doses of cyclosporine and IFN-gamma expressed increased rejection at 20 days that had resolved completely by 45 days post-transplantation. Polymorphonuclear leukocytes (neutrophils) were isolated from the blood of rats, and their function was determined by treating the cells with f-Met-Leu-Phe (fMLP) and measuring superoxide produced. Results indicate that the neutrophils from rats treated with maintenance doses of cyclosporine and IFN-gamma still had increased IFN-gamma-modulated fMLP-induced respiratory burst and that maintenance cyclosporine therapy can inhibit the IFN-gamma-mediated accelerated rejection without compromising the antimicrobial effects of IFN-gamma treatment.
A D Slater; J B Klein; C W Czarniecki; G Sonnenfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of interferon research     Volume:  13     ISSN:  0197-8357     ISO Abbreviation:  J. Interferon Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-07     Completed Date:  1994-03-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100396     Medline TA:  J Interferon Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  IM; S    
Department of Surgery, School of Medicine, University of Louisville, KY 40292.
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MeSH Terms
Cyclosporine / pharmacology
Drug Interactions
Graft Rejection / prevention & control*
Heart Transplantation*
Interferon-gamma, Recombinant / pharmacology*
Neutrophils / drug effects*
Rats, Inbred ACI
Rats, Inbred Lew
Respiratory Burst / drug effects
Transplantation, Heterotopic*
Reg. No./Substance:
0/Interferon-gamma, Recombinant; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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