| The effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. | |
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MedLine Citation:
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PMID: 21799131 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Injury to the airway epithelium has been proposed as a key susceptibility factor for exercise-induced bronchoconstriction (EIB). Our goals were to establish whether airway epithelial cell injury occurs during EIB in athletes and whether inhalation of warm humid air inhibits this injury. Twenty one young male athletes (ten with a history of EIB) performed two 8 min exercise tests near maximal aerobic capacity in cold dry (4°C, 37% relative humidity) and warm humid air (25°C, 94% relative humidity) on separate days. Post-exercise changes in urinary CC16 were used as a biomarker of airway epithelial cell perturbation and injury. Bronchoconstriction occurred in eight athletes in the cold dry environment and was completely blocked by inhalation of warm humid air (maximal fall in forced expiratory volume in one sec: 18.1 ± 2.1 (SD) % in cold dry vs 1.7 ± 0.8 % warm humid air, P<0.01). Exercise caused an increase in urinary excretion of CC16 in all subjects (P<0.001), but this rise in CC16 was blunted following inhalation of warm humid air (median CC16 increase pre- to post-challenge in athletes with EIB: cold dry 1.91 ng.μmol(-1) vs warm humid 0.35 ng.μmol(-1), P=0.017; athletes without EIB: cold dry 1.68 ng.μmol(-1) vs warm humid 0.48 ng.μmol(-1), P=0.002). The results indicate that exercise hyperpnea transiently disrupts the airway epithelium of all athletes (not only in those with EIB) and that inhalation of warm moist air limits airway epithelial cell perturbation and injury. |
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Authors:
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Claire Bolger; Ellen Tufvesson; Sandra D Anderson; Graham Devereux; Jon G Ayres; Leif Bjermer; Malcolm Sue-Chu; Pascale Kippelen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Aberdeen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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