| The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. | |
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MedLine Citation:
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PMID: 19010528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congestive heart failure (CHF) is a chronic disease with a high mortality rate. Managing CHF patients has been one of the most severe health care problems for years. Scaffold materials have been predominantly investigated in acute myocardial infarction (MI) studies and have shown promising improvement in LV function. In this study we examined whether surface modification of a biomaterial can influence the myocardial microenvironment and improve myocardial function in a rodent model of ischemic cardiomyopathy. In vitro cell culture and in vivo rat studies were performed. RGD peptides conjugated to alginate improved human umbilical vein endothelial cell (HUVEC) proliferation and adhesion when compared to a non-modified alginate group. Injection of the alginate hydrogel into the infarct area of rats 5 weeks post-MI demonstrated that both modified and non-modified alginate improve heart function, while LV function in the control group deteriorated. Both the RGD modified alginate and non-modified alginate increased the arteriole density compared to control, with the RGD modified alginate having the greatest angiogenic response. These results suggest that in situ use of modified polymers may influence the tissue microenvironment and serve as a potential therapeutic agent for patients with chronic heart failure. |
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Authors:
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Jiashing Yu; Yiping Gu; Kim T Du; Shirley Mihardja; Richard E Sievers; Randall J Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-17 |
Journal Detail:
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Title: Biomaterials Volume: 30 ISSN: 1878-5905 ISO Abbreviation: Biomaterials Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 751-6 Citation Subset: IM |
Affiliation:
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University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley/San Francisco, CA, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alginates
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pharmacology* Animals Cell Adhesion / drug effects Cell Proliferation / drug effects Cells, Cultured Disease Models, Animal Female Glucuronic Acid / pharmacology Hexuronic Acids / pharmacology Humans Myocardial Infarction / drug therapy Oligopeptides / chemistry* Rats Rats, Sprague-Dawley Ventricular Function, Left / drug effects* Ventricular Remodeling / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Hexuronic Acids; 0/Oligopeptides; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; 99896-85-2/arginyl-glycyl-aspartic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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