| The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4. | |
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MedLine Citation:
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PMID: 12635579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhaled heparin has been shown to reduce the early and late phase of asthmatic reactions and suppress an allergen-induced increase in bronchial hyperreactivity. The mechanism involved in the control of bronchial hyperreactivity in asthma by heparin is still not understood. The purpose of this study was to investigate the effect of inhaled heparin on the airway response to histamine and leukotriene D4. Children with a typical history of mild allergic asthma participated in this randomized, double-blind, placebo-controlled cross-over study. Subjects underwent provocation challenge tests with histamine or leukotriene D4 before and after inhalation of heparin and placebo. Twenty-three patients completed the study. We showed that placebo did not affect the bronchial hyperreactivity to histamine or leukotriene. A single dose of inhaled heparin significantly decreased bronchial hyperreactivity to histamine and leukotriene in children with mild asthma. Results of our study suggest that inhaled heparin, because of its antiallergic and/or anti-inflammatory properties, modifies airway hyperresponsiveness in children with allergic asthma. |
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Authors:
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Iwona Stelmach; Joanna Jerzynska; Wlodzimierz Stelmach; Pawel Majak; Agnieszka Brzozowska; Pawel Gorski; Piotr Kuna |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Allergy and asthma proceedings : the official journal of regional and state allergy societies Volume: 24 ISSN: 1088-5412 ISO Abbreviation: Allergy Asthma Proc Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-03-14 Completed Date: 2003-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9603640 Medline TA: Allergy Asthma Proc Country: United States |
Other Details:
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Languages: eng Pagination: 59-65 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Allergy, M. Curie Hospital, 35 Parzeczewska Street, 95-100 Zgierz, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Anti-Inflammatory Agents / administration & dosage, therapeutic use* Bronchial Hyperreactivity / chemically induced*, drug therapy*, physiopathology Bronchial Provocation Tests Bronchoconstrictor Agents / adverse effects* Child Child Welfare Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Female Forced Expiratory Volume / drug effects Heparin / administration & dosage, therapeutic use* Histamine / adverse effects* Humans Leukotriene D4 / adverse effects* Male Nasal Provocation Tests Predictive Value of Tests Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Bronchoconstrictor Agents; 51-45-6/Histamine; 73836-78-9/Leukotriene D4; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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