| The effect of inhaled fenoterol and ipratropium bromide on propranolol induced bronchoconstriction in the asthmatic airways. | |
| | |
MedLine Citation:
|
PMID: 2149088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The provocative dose of inhaled propranolol, (PC20P, mg/mL) needed to induce a 20% reduction in the forced expired volume in 1 s (FEV1, L) was determined for 15 adult asthmatics following randomized pre-treatment with placebo, ipratropium bromide (40, 160 micrograms) and fenoterol (200, 800 micrograms) aerosols using a double-blind protocol. 2. Fenoterol 200 micrograms, 800 micrograms increased the baseline FEV1 0.28 +/- 0.16, 0.32 +/- 0.16 L (P = 0.04, P = 0.008 respectively). Fenoterol 800 micrograms moved the PC20 P rightwards from placebo geometric mean 10.95, 95% Confidence Intervals (95% CI) 4.43-27.22 mg/mL to mean 20.41, 95% CI 10.13 to 40.64 mg/mL (P = 0.01). Fenoterol 200 micrograms was not protective; mean PC20 16.22, 95% CI 7.83-34.35 mg/mL (P = 0.08). Neither 40 or 160 micrograms ipratropium changed the FEV1 or PC20P values compared with placebo; increase in FEV1 0.15 +/- 0.27 L (P = 0.22), 0.24 +/- 0.12 L (P = 0.14) and geometric mean PC20P 16.59 +/- 0.57 mg/mL, 95% CI 8.01-34.51 mg/mL (P = 0.90), 15.58 +/- 0.66 mg/mL, 95% CI 6.72-36.05 mg/mL (P = 0.34) respectively after ipratropium treatments. 3. Bronchoconstriction induced by inhaled propranolol (P) appears to be only weakly antagonized by inhaled beta-agonist and not reduced by antimuscarinic anticholinergic aerosol. This finding argues against the activation of a cholinergic reflex to explain propranolol induced bronchoconstriction (PIB). |
| | |
Authors:
|
K M Latimer; R E Ruffin |
Related Documents
:
|
22188158 - Considerations in the development of an in vitro dissolution condition for lacidipine t... 157338 - Clinical pharmacology of a combination of bronchodilators. 20528598 - Sodium cromoglycate alone and in combination with montelukast on the airway response to... 3571768 - Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-usi... 17041398 - Effect of minidose aspirin on renal function and renal uric acid handling in healthy yo... 11035278 - Antenatal steroid treatment and adverse fetal effects: what is the evidence? |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 17 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1990 Sep |
Date Detail:
|
Created Date: 1991-03-11 Completed Date: 1991-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 627-35 Citation Subset: IM |
Affiliation:
|
Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, South Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Adult Aged Asthma / physiopathology* Bronchoconstriction / drug effects* Double-Blind Method Female Fenoterol / pharmacology* Humans Ipratropium / pharmacology* Male Middle Aged Propranolol / administration & dosage, antagonists & inhibitors* Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
|
13392-18-2/Fenoterol; 525-66-6/Propranolol; 60205-81-4/Ipratropium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramida...
Next Document: Cholelithiasis. Laparoscopic treatment with intracorporeal lithotripsy followed by cholecystostomy o...