Document Detail


The effect of inhaled bronchoconstrictors on transcutaneous gas tensions in normal adult subjects.
MedLine Citation:
PMID:  3673787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The administration of histamine and leukotriene D4 (LTD4) by nebulised aerosol in logarithmically increasing doses to normal subjects resulted in significant bronchoconstriction. Transcutaneous oxygen tension (tcPO2) was monitored during and after the bronchial challenge tests. Following histamine challenge there was significant hypoxaemia in all subjects (mean fall in tcPO2, 20 mmHg). However, following LTD4 administration, there was a small and insignificant fall in tcPO2. Transcutaneous carbon dioxide tension (tcPCO2) was also monitored throughout bronchial challenge, but showed no significant change. We suggest that the hypoxaemia following histamine challenge was due to increased ventilation/perfusion (V/Q) mismatching in the lung induced by histamine deposition.
Authors:
B Gray; N Barnes
Related Documents :
7251447 - Inhalation patterns and predominant site of bronchoconstriction in healthy subjects.
24524697 - Effects of ingesting low glycemic index carbohydrate food for the sahur meal on subject...
3952587 - Respiratory heat loss in exercise-induced asthma. measurement and clinical application.
17395017 - Reduced thioredoxin increases proinflammatory cytokines and neutrophil influx in rat ai...
8905187 - Oxygen deficit: a measure of the anaerobic energy production during intense exercise?
8769347 - Exercise increases serum testosterone and sex hormone-binding globulin levels in older ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  220     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Affiliation:
Department of Thoracic Medicine, King's College School of Medicine & Dentistry, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Blood Gas Monitoring, Transcutaneous*
Dose-Response Relationship, Drug
Female
Histamine / analogs & derivatives*,  pharmacology
Humans
Male
Pulmonary Gas Exchange / drug effects*
SRS-A / pharmacology*
Chemical
Reg. No./Substance:
0/SRS-A; 51-45-6/Histamine; 51-74-1/histamine phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transcutaneous oxygen tension during exercise in patients with pulmonary emphysema.
Next Document:  In vivo calibration of a transcutaneous oxygen electrode in adult patients.