Document Detail

The effect of inhaled bronchoconstrictors on transcutaneous gas tensions in normal adult subjects.
MedLine Citation:
PMID:  3673787     Owner:  NLM     Status:  MEDLINE    
The administration of histamine and leukotriene D4 (LTD4) by nebulised aerosol in logarithmically increasing doses to normal subjects resulted in significant bronchoconstriction. Transcutaneous oxygen tension (tcPO2) was monitored during and after the bronchial challenge tests. Following histamine challenge there was significant hypoxaemia in all subjects (mean fall in tcPO2, 20 mmHg). However, following LTD4 administration, there was a small and insignificant fall in tcPO2. Transcutaneous carbon dioxide tension (tcPCO2) was also monitored throughout bronchial challenge, but showed no significant change. We suggest that the hypoxaemia following histamine challenge was due to increased ventilation/perfusion (V/Q) mismatching in the lung induced by histamine deposition.
B Gray; N Barnes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  220     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Department of Thoracic Medicine, King's College School of Medicine & Dentistry, London, U.K.
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MeSH Terms
Administration, Inhalation
Blood Gas Monitoring, Transcutaneous*
Dose-Response Relationship, Drug
Histamine / analogs & derivatives*,  pharmacology
Pulmonary Gas Exchange / drug effects*
SRS-A / pharmacology*
Reg. No./Substance:
0/SRS-A; 51-45-6/Histamine; 51-74-1/histamine phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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