Document Detail

The effect of infusions of plasma and of saline on the renal response to water-loading in sodium-depleted dogs.
MedLine Citation:
PMID:  5666178     Owner:  NLM     Status:  MEDLINE    
1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2.5% body weight of water by mouth.2. Infusion of 300 ml. of saline (0.73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow.3. Infusion of 100 ml. of saline (0.73g NaCl/100 ml.) to sodium-depleted dogs restores their ability to respond to a water-load of 2.5% of body weight by diuresis.4. The results are discussed and a tentative explanation put forward.
R V Coxon; D J Ramsay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  197     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1968 Aug 
Date Detail:
Created Date:  1968-09-25     Completed Date:  1968-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  631-8     Citation Subset:  IM    
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MeSH Terms
Hyponatremia / physiopathology*
Infusions, Parenteral
Kidney / physiopathology*
Peritoneal Dialysis
Sodium Chloride*
Water-Electrolyte Balance*
Reg. No./Substance:
50-99-7/Glucose; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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