Document Detail


The effect of indomethacin tocolysis on maternal coagulation status.
MedLine Citation:
PMID:  7936519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effect of indomethacin tocolysis on maternal coagulation. METHODS: Twenty gravidas at 24-32 weeks' gestation were treated for preterm labor with 50 mg indomethacin orally, followed by 25 mg every 6 hours for 3 days. Bleeding time, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were measured before and 48 hours after initiation of therapy. Statistical analysis was performed by paired t test and Fisher exact test. RESULTS: The typical participant was 22 years old, nulliparous, and 26.2 weeks' gestational age at enrollment. The mean bleeding time was 4.5 minutes before therapy and 8.8 minutes after therapy (P < .0001, mean difference 4.3 minutes, 95% confidence interval 2.9-5.8). Nineteen of the 20 subjects experienced an increase in bleeding time and 13 had abnormal bleeding times. No clinically significant changes in PT or aPTT were noted. The mean period from treatment to delivery was 60.2 days. No cases of neonatal intraventricular hemorrhage or maternal postpartum hemorrhage were noted. CONCLUSION: Oral indomethacin treatment for tocolysis has no impact on PT and aPTT; however, profound acute changes in maternal bleeding time occur.
Authors:
C C Lunt; A J Satin; W H Barth; G D Hankins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-11-16     Completed Date:  1994-11-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  820-2     Citation Subset:  AIM; IM    
Affiliation:
Wilford Hall United States Air Force Medical Center/PSO, Lackland Air Force Base, Texas.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Bleeding Time
Blood Coagulation / drug effects*
Female
Humans
Indomethacin / administration & dosage,  pharmacology*
Obstetric Labor, Premature / drug therapy
Partial Thromboplastin Time
Pregnancy
Prothrombin Time
Tocolysis*
Chemical
Reg. No./Substance:
53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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