| The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome. | |
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MedLine Citation:
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PMID: 1251764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 19 nephrotic patients on a dietary intake of 20 mEq sodium/24 hours, indomethacin caused an immediate decrease in glomerular filtration rate (GFR) and urinary protein excretion, an effect completely reversible upon withdrawal of the drug. As a consequence of lower protein excretion, there was eventually a rise in GFR. It is proposed that the therapeutic effect of indomethacin in nephrotic syndrome is caused by its inhibiting action on renal prostaglandin synthesis, thereby potentiating the effect of the renin-angiotensin system on the kidney. The difference between the decrease in GFR (mean 35%) and proteinuria (mean 55%) and the more selective proteinuria during indomethacin administration may be explained by quantitative and qualitative differences in protein leakage between outer cortical and inner cortical nephron populations. |
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Authors:
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L Arisz; A J Donker; J R Brentjens; G K van der Hem |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 199 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1976 |
Date Detail:
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Created Date: 1976-04-10 Completed Date: 1976-04-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Depression, Chemical Female Follow-Up Studies Glomerular Filtration Rate / drug effects* Humans Indomethacin / pharmacology, therapeutic use* Male Middle Aged Nephrotic Syndrome / drug therapy* Proteinuria / metabolism* |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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