Document Detail

The effect of indomethacin and prostaglandin (PGE2) on renal failure due to glycerol in saline-loaded rats.
MedLine Citation:
PMID:  1192709     Owner:  NLM     Status:  MEDLINE    
1. Acute renal failure was induced in conscious rate by subcutaneous injection of glycerol. 2. Expansion of the extracellular space by infusion of 150 mmol/l sodium chloride (saline) partly protected the animals against acute renal failure. 3. This protective effect of saline infusion disappeared when the animals were treated with indomethacin. This effect could be reversed by the addition of prostaglandin (PGE2) to the saline infusion. 4. We suggest that prostaglandins may be involved in mediating the protection afforded by saline infusion against acute renal failure due to glycerol.
N Papanicolaou; P Callard; J Bariety; P Milliez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  49     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  IM    
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MeSH Terms
Creatinine / blood
Indomethacin / pharmacology*
Infusions, Parenteral
Kidney Failure, Acute / chemically induced,  prevention & control*
Prostaglandins E / pharmacology*
Sodium Chloride / administration & dosage,  antagonists & inhibitors,  therapeutic use*
Reg. No./Substance:
0/Prostaglandins E; 53-86-1/Indomethacin; 56-81-5/Glycerol; 60-27-5/Creatinine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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