Document Detail


The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung.
MedLine Citation:
PMID:  3511937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise. In a double-blind randomized study we have determined the effects of both acute (50 mg) and chronic (25 mg twice daily for 7 days) oral treatment with indomethacin on breathlessness induced by exercise in patients with diffuse parenchymal disease of the lung. The relationship of breathlessness, as measured on a visual analogue scale, to ventilation was not significantly altered by either acute or chronic treatment with indomethacin compared to placebo. There was no significant change in the distance walked in 6 minutes after any of the treatments. Possible explanations for the differing effects on breathlessness observed in normal subjects and in patients are discussed.
Authors:
P A O'Neill; T B Stretton; R D Stark; S H Ellis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of diseases of the chest     Volume:  80     ISSN:  0007-0971     ISO Abbreviation:  Br J Dis Chest     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-18     Completed Date:  1986-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7511123     Medline TA:  Br J Dis Chest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  72-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Double-Blind Method
Dyspnea / drug therapy*,  physiopathology
Exercise Test
Female
Forced Expiratory Volume
Humans
Indomethacin / therapeutic use*
Lung / physiopathology
Male
Middle Aged
Physical Exertion
Pulmonary Fibrosis / physiopathology
Random Allocation
Vital Capacity
Chemical
Reg. No./Substance:
53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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