Document Detail

The effect of an individual's blood pressure on the percentage of total 7,12-dimethylbenz[a] anthracene metabolites that bind covalently to DNA in cultured resting lymphocytes.
MedLine Citation:
PMID:  6793249     Owner:  NLM     Status:  MEDLINE    
A method for the quantitative analysis of the percent metabolism that results in covalent binding of 7,12-dimethylbenz[a]anthracene (DMBA) to DNA in viable resting human lymphocytes is described. The inter- and intra-experimental reproducibility as judged by the coefficient of variation and examined in the same individual over a 3-month period was 31.4% and 13.9%, respectively. When the lymphocytes from 30 hypertensive individuals were exposed to 1 microM DMBA for 18 h, the percent of total DMBA metabolites that bind DNA covalently was correlated to the blood pressures of the patients at the time of sampling (r = 0.53, P less than 0.005). No influences on the data from the type or duration of hypertensive drug treatment could be statistically determined for this sample of hypertensive patients. It was concluded that high blood pressure is a strong determinant in predisposing lymphocytes to increased genetic risk from induced DNA damage and that this relationship is not statistically affected by hypertensive drug therapy.
R W Pero; C Bryngelsson; C Ostlund; T Bryngelsson; A Norden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  37     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-22     Completed Date:  1981-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
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MeSH Terms
9,10-Dimethyl-1,2-benzanthracene / blood*
Aryl Hydrocarbon Hydroxylases / blood
Benz(a)Anthracenes / blood*
Cells, Cultured
DNA / blood*
Dose-Response Relationship, Drug
Hypertension / blood*
Lymphocytes / metabolism*
Middle Aged
Reg. No./Substance:
0/Benz(a)Anthracenes; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 9007-49-2/DNA; EC Hydrocarbon Hydroxylases

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