| The effect of imprecise repositioning on lesion volume measurements in patients with multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 9222208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this study, we evaluated the effect of imprecision in patient repositioning encountered in real life on multiple sclerosis (MS) lesion volumes measured from MRIs. We also evaluated two putative methods for reducing the variability in these lesion volume measurements: first, a reduction of slice thickness (from the conventional 5 mm to 3 mm) and second, the application of a new repositioning technique based on the use of head immobilization shells. We evaluated the errors in lesion volume by scanning 10 patients a total of four times using the two slice thicknesses and two repositioning methods (conventional and using a head immobilization shell). The mean absolute percentage difference between two corresponding scans was 6.8% (range, 1.24 to 11%) using conventional slice thickness and repositioning, 4.1% (range, 0.7 to 5.56%) using conventional slice thickness and head immobilization shells, 2.6% (range, 0.8 to 6.66%) using the conventional repositioning technique and 3-mm slice thickness, and 1.4% (range, 0.2 to 6.14%) using slice thickness of 3 mm and head immobilization shells. These mean absolute differences were significantly different (p = 0.0008). Our results indicate that the effect of repositioning errors of the order of those that can be encountered in the daily life situation of clinical trials affects significantly lesion load measurements in MS and that the combined use of thinner slices and more accurate repositioning techniques can markedly improve the reproducibility of such measurements. |
| | |
Authors:
|
M Filippi; N Marcianò; R Capra; M A Rocca; F Prandini; R Gasparotti; M A Horsfield; G Comi |
Related Documents
:
|
23363118 - Advantages from bilateral hearing in speech perception in noise with simulated cochlear... 16554568 - Inherent variability of ct lung nodule measurements in vivo using semiautomated volumet... 23377078 - Mechanical evaluation of an implant-abutment self-locking taper connection: finite elem... 266828 - Proprotionate linear measurements in radiographic cephalometric assessments. a methodol... 11324208 - Early implant failures in patients treated with brånemark system titanium dental impla... 20640358 - Preload loss and bacterial penetration on different implant-abutment connection systems. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurology Volume: 49 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 274-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain / pathology* Female Histocytochemistry Humans Magnetic Resonance Imaging Male Multiple Sclerosis / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Next Document: Assessment of digital EEG, quantitative EEG, and EEG brain mapping: report of the American Academy o...