Document Detail


The effect of immobilization on collagen turnover in connective tissue: a biochemical-biomechanical correlation.
MedLine Citation:
PMID:  7090757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immobilization of the knee joint for 9 weeks results in a reduction of the mechanical properties in the lateral collateral ligament. Specifically, ligament stiffness is reduced in this tissue. No statistical change in collagen mass was detected for the medial collateral ligament (MCL) or patellar tendon. An increase in collagen turnover (synthesis and degradation) was, however, found in the immobilized medial collateral ligament and patellar tendon. It is thus proposed that stiffness reduction is due to a change in the ligament substance itself, rather than a result of tissue atrophy.
Authors:
D Amiel; S L Woo; F L Harwood; W H Akeson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  53     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Collagen / biosynthesis,  metabolism*
Connective Tissue / metabolism*,  physiology
Hydroxyproline / analysis
Immobilization*
Knee Joint / physiology*
Ligaments, Articular / physiology*
Male
Patella
Proline / pharmacology
Rabbits
Tendons / physiology
Grant Support
ID/Acronym/Agency:
AM 00304/AM/NIADDK NIH HHS; AM 14918/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
147-85-3/Proline; 51-35-4/Hydroxyproline; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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