| The effect of immediate postpartum depot medroxyprogesterone on early breastfeeding cessation. | |
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MedLine Citation:
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PMID: 23153897 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: This study evaluated the effect of immediate postpartum depot medroxyprogesterone (DMPA) on breastfeeding cessation within 6 weeks postpartum. STUDY DESIGN: At low-income-serving obstetric and pediatric clinics, eligible mothers within 1 year postpartum were recruited to participate in a retrospective cohort study. The 183 participants completed a self-administered survey. Surveys were merged with birth certificate data and perinatal maternal/infant medical records. Kaplan-Meier distributions assessed the relationship between DMPA use and breastfeeding cessation. A multivariable Cox proportional hazards model estimated hazard ratios (HRs) and included five known risk factors (age, education, race, parity and parental cohabitation) and identified potential confounders. RESULTS: Consistent with the biologic model, the Kaplan-Meier results raised the possibility of a detrimental effect of DMPA on duration of any breastfeeding, but differences in these distributions did not achieve statistical significance (p=.24); after adjustment for potential confounders, this nonstatistically significant association remained (HR: 1.22; confidence interval: 0.75-1.98). CONCLUSION: Given the state of the evidence, it is unclear whether a causal effect does or does not exist. However, if there is a causal effect of DMPA on breastfeeding duration, it is minimal. Additional well-designed research is warranted. |
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Authors:
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Elizabeth A Brownell; I Diana Fernandez; Susan G Fisher; Cynthia R Howard; Sharon R Ternullo; Ruth A Lawrence; Joseph W Duckett; Ann M Dozier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
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Title: Contraception Volume: - ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Neonatology, Connecticut Children's Medical Center, Hartford, CT 06106, USA; Division of Research, Connecticut Children's Medical Center, Hartford, CT 06106, USA. Electronic address: EBrownell@CCMCKids.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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