Document Detail

The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients.
MedLine Citation:
PMID:  358295     Owner:  NLM     Status:  MEDLINE    
In 12 dysmenorrheic patients we examined the therapeutic action of the Prostaglandin-synthesis inhibitor: Ibuprofen, a non-steroidal analgesic agent. Ibuprofen highly significantly reduced the resting pressure (P less than 0.001), active pressure (P less than 0.001) and frequency (P less than 0.05) of cyclic activity of the uterus, as well as menstrual pain (P less than 0.001). Since these effects occurred after a single oral dose of 800 mg Ibuprofen, without side effects or complications, extensive field trials are recommended with this and other PG-synthesis inhibitors, to assess their therapeutic benefits.
12 dysmenorrheic volunteers (average age, 28 years) were studied after treatment with Ibuprofen, a nonsteroidal antiinflammatory agent. Intrauterine pressure was recorded after either placebo or Ibuprofen oral administration. 800-mg doses were used. The therapeutic action of this prostaglandin inhibitor was highly significant in reducing resting pressure (P.001), active pressure (P.001), and frequency of contractions (P.05). In addition, menstrual pain was significantly reduced (P.05). The success of this single dose of 800 mg makes feasible a more comprehensive clinical trial of Ibuprofen's therapeutic effects.
M O Pulkkinen; A I Csapo
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  15     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1055-62     Citation Subset:  IM; J    
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MeSH Terms
Administration, Oral
Clinical Trials as Topic
Drug Evaluation
Dysmenorrhea / drug therapy*
Ibuprofen / administration & dosage,  therapeutic use*
Menstruation Disturbances / drug therapy*
Uterus / physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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